Stanford Accelerated Intelligent Neuromodulation Therapy (SAINT) is a unique, personalized TMS protocol developed under the supervision of Prof. Nolan Williams from the Brain Stimulation Lab at Stanford University in California. It is probably the most effective therapy for drug-resistant depression, achieving about an 80% remission rate confirmed by clinical trials. SAINT is a veritable marathon consisting in completing 50 iTBS sessions over five days (10 sessions per day, every 50 minutes). The total dose of TMS in this protocol corresponds to six standard therapies. What distinguishes the original SAINT protocol from other protocols is not only the use of a vast number of magnetic pulses in a very short time. The innovation lies in using special software to select the best stimulation site based on analyzing the so-called anticorrelation between the cingulate gyrus and the cerebral cortex. Functional magnetic resonance imaging (fMRI) is used for this. This software has been patented by the American company Magnus Medical as The SAINT® Neuromodulation System and in 2022, officially received US FDA approval for the treatment of drug-resistant depression. However, the original SAINT® is still not available anywhere and awaits implementation. Meanwhile, many clinics worldwide perform a similar protocol without the use of neuronavigation with slightly worse results. Similarly, in Magwise, as the first in Poland, since 2020, we have been performing a 5-day therapy inspired by the SAINT protocol, the effect of which is dozens of satisfied patients.