Diseases treated at the magwise clinic

Parkinson's disease

Parkinson's disease is a chronic, progressive neurodegenerative disorder that affects the human nervous system. It was first described by James Parkinson in 1817.

What causes Parkinson's disease?

Medically, the disease is caused by the loss of nerve cells in the area of the brain responsible for movement control and coordination. In a less medical attempt to characterize Parkinson's disease, the patient loses the ability to function and the power over his limbs, face, tremors take over speech, stiffening of the muscles, monotony of the voice, etc. Functioning without control over your own body is extremely difficult. We know that Parkinson's disease is caused by a loss of dopamine. It is a crucial neurotransmitter responsible for transmitting signals in the brain. The causes of Parkinson's disease and the failure of nerve cells are still unknown. Both genetic and environmental factors are believed to be responsible for Parkinson's disease.

Parkinson's disease - symptoms:

The symptoms of Parkinson's disease can vary, but the most common are:

  • Trembling
  • Muscle stiffness
  • Balance disorders and slow movement
  • Posture disorders
  • Difficulty speaking and swallowing
  • Rest tremors and shaking hands
  • Psychiatric symptoms include:
  • Emotional instability and depression
  • Changes in the functioning of the autonomic nervous system, such as problems controlling blood pressure and difficulty urinating.

The course of Parkinson's disease

There is no single correct scenario for Parkinson's disease. Parkinson's disease can vary from person to person, but it is a progressive condition overall. In a typical course, the stages of Parkinson's disease are distinguished:

At the initial stage, here are no significant symptoms of the disease. There may be subtle symptoms, such as a slight tremor in one hand or resistance to movement. Among the early signs of Parkinson's disease, there may also be a subtle slowing of movements and mild balance problems. These symptoms may be mild at first and belittled.

Intermediate stage. As the disease progresses, symptoms become more noticeable and affect daily functioning. The tremors and stiffness may become more severe, and the slowness of movement may make it difficult to perform simple activities such as writing or dressing. Balance problems may also occur, which increases the risk of falls.

Advanced stage. In the advanced stages of Parkinson's disease, the symptoms are more severe and significantly affect the patient's ability to carry out daily activities. Muscle stiffness can be very burdensome, limiting mobility and leading to difficulty walking. In the advanced stage, there may also be difficulties with speaking, impaired balance and coordination, and problems with swallowing.

Advanced stage with complications. In some cases, after many years of Parkinson's disease, treatment-related complications may arise. Among them may be: Fluctuations in the action of drugs, the so-called on-off when symptoms improve and worsen irregularly, dyskinesias (uncontrollable movements), and neuropsychiatric disorders such as hallucinations and memory problems.

The course of Parkinson's disease is very individual and may vary from patient to patient. Parkinson's disease affects the patients, their families, loved ones, and social functioning. It requires a multifaceted approach, care, and support from medical professionals to help patients manage their symptoms and maintain the best possible quality of life.

Treatment of Parkinson's disease

The goal of treatment of Parkinson's disease is to alleviate its symptoms and improve the patient's quality of life. Unfortunately, Parkinson's disease, despite a lot of knowledge about it, is still a disease whose effects can be mitigated but not cured.
  • pharmacotherapy
  • physical rehabilitation
  • psychological support
  • non-invasive methods of brain stimulation (TMS, TPS) - there is an increasing amount of scientific evidence for the effectiveness of both methods, especially in cases where symptoms become significantly limiting to everyday functioning
  • neurosurgical treatment - the so-called deep brain stimulation (DBS), i.e., implantation of an implant (electrode) that sends electrical impulses to a specific part of the brain and allows modulation of its activity.

Parkinson's disease treatment available at Magwise

  • Pharmacological treatment under the supervision of a specialist neurologist
  • Psychological support
  • Programming electrodes for DBS deep brain stimulation
  • TMS Neurostimulation (Transcranial Magnetic Stimulation)
  • TPS® neurostimulation (transcranial impulse stimulation)

References

Wagle Shukla A, Shuster JJ, Chung JW, Vaillancourt DE, Patten C, Ostrem J, Okun MS. Repetitive Transcranial Magnetic Stimulation (rTMS) Therapy in Parkinson Disease: A Meta-Analysis. PM R. 2016 Apr;8(4):356-366. PMCID: PMC5540142.

Deng S, Dong Z, Pan L, Liu Y, Ye Z, Qin L, Liu Q, Qin C. Effects of repetitive transcranial magnetic stimulation on gait disorders and cognitive dysfunction in Parkinson's disease: A systematic review with meta-analysis. Brain Behav. 2022 Aug;12(8):e2697. PMCID: PMC9392523.

Li R, He Y, Qin W, Zhang Z, Su J, Guan Q, Chen Y, Jin L. Effects of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Parkinson's Disease: A Meta-Analysis. Neurorehabil Neural Repair. 2022 Jul;36(7):395-404. PMID: 35616427.